We want to Thank you ordering our monographs or books through our website bookstore. Note that while all PDF purchases can be downloaded immediately (through the email link sent to you), all printed books will be back-ordered until July 22, 2024. If you order a printed book before then, they will be shipped on July 22. We are sorry for this inconvenience.

For those looking for Print copies of our Supplementing Dietary Nutrient Roadmap (First Edition)- we are officially out of stock awaiting the delivery of our Second Edition (a nearly complete rewrite and expansion of the first). Currently, the first edition eBook is still available (here), and the eBook version of the second edition will be uploaded to our bookstore very soon.

We have been asked many times over the past few years about providing PDF versions of our books for easy download; and especially for international purchases- to avoid costly shipping. Our bookstore now has all the Titles in both Print and PDF-eBook forms (you can purchase both as a bundle for an additional discount).

The Cardiometabolic Road map is finally back from the printer and ready to be shipped. Why did it take so long…… Well, when you hold the 350 page book (yes 100 pages longer than the GI Road map) and see all the illustrations and references you should be asking how it got done so quickly! In either case, this Road map is the culmination of over 18 months of research, writing, editing, illustrating, proofing and assembling; we are certain you will not be disappointed.


We also worked hard to keep this affordable. While it is 40% larger than our GI Roadmap, we worked with our printer to keep the cost very reasonable and at our normal retail price ($54.95) it is only $5 more than our GI book. However, we will be selling the book for only $49.95 during the month of July (2018) to celebrate this achievement and get these out to as many of our customers as possible. So order yours today and don’t miss out on this early bird special.


You can find our order page here: https://www.pointinstitute.org/shop/


Cardiometabolic Road map coming This Spring!

Many of you have been asking us “When is the next Road map going to be ready” and we can now tell you that our target is to have it ready to ship this spring (2018). As you can imagine if you have read any of our previous Road maps, the amount of relevant information published in the cardiometabolic field is probably more than any other, and the number of lifestyle and nutrient-related remedies that have been investigated is vast. All of which means that we are sifting through mounds of information to bring you the sort of informed, balanced and evidence-based approach that we have taken with each of our other projects (though this one is slated to be a bit larger than the previous GI book). We realize that this has taken longer than we (or you) would have liked, but in addition to the tremendous breadth of this topic (and due to the publication of the previous books), Dr. Guilliams has had additional speaking and writing requests over the past year that were unanticipated. We want to thank you for your patience and hope not to rely upon it much longer. We will let all of you know when we are ready to take pre-orders for the new book and maybe provide a sneak peak of a portion in the very near future. Stay warm, spring is just around the corner.

We have recently posted a new whitepaper that outlines our continued concern over the current use of Red Yeast Rice supplements by clinicians. As our whitepaper details, these products are not reliably effective and many are of dubious legal status. If you use or recommend RYR products, please read the entire whitepaper to see this important information

RYR Whitepaper

Dr. Guilliams was recently interviewed by Dr. Hoffman for his “Intelligent Medicine” podcast. Dr. Hoffman was given an early version of Dr. Guilliams’ new book “Functional Strategies for the Management of Gastrointestinal Disorders,” much of which was touched upon in this fast-paced and wide-ranging interview. You can listen to the podcast (in two segments) here: Part 1 and Part 2.

For a visual sneak peak of the book (and to take advantage of our pre-shipping sale through November 2016, check out the GI book page.




Artificial sweeteners such as aspartame (NutraSweet®, Equal®), sucralose (Splenda®), and saccharin (Sweet’N Low®) are ubiquitous in processed foods and beverages; and are regularly consumed by 1/3 of all Americans in a variety of “diet” products.[i]  While designed to be low calorie alternatives to sugar, research has repeatedly shown that consumption of these artificial sweeteners is still linked to metabolic derangements such as weight gain, impaired glucose tolerance and increased incidence of type 2 diabetes.[ii],[iii] Now, research has discovered that while most of these synthetic sweeteners are excreted unchanged in either the urine or feces, they affect metabolism through alterations of the gut microbiota.

In an animal model, Suez et al. showed aspartame, sucralose and saccharin induced glucose intolerance over eight and eleven weeks; further study of saccharin demonstrated the effects were mediated through compositional and functional changes to the gut microbiota, with more than 40 operational taxonomic units altered in the saccharin-fed group.[iv]  Interestingly, Akkermansia muciniphila was underrepresented in the mice fed saccharin. Using antibiotics and transplanting fecal microbiota samples into germ-free mice, the group linked the impaired glucose tolerance to an altered microbiome.

The group then studied the effects of artificial sweeteners in a small-scale human intervention study. Seven subjects (who did not normally consume artificial sweeteners) consumed a regular diet supplemented with the upper limit of daily saccharin dose (5 mg/kg/day) for one week. Four of the seven volunteers showed an elevated glycemic response (responders), and the other three individuals showed no response. The researchers transplanted the four responders’ microbiota into germ-free mice and replicated the impaired glucose response, again linking the metabolic effects to the altered microbiota.  The responder/non-responder effect suggests that not all individuals are affected equally by artificial sweetener consumption, and the response may depend on an individual’s baseline microbiota.[v] Although this is one of the few human intervention trials available to show the effect of artificial sweeteners on the microbiome, other animal studies using these ingredients (at relevant dietary doses) suggests that this phenomena is an important link between artificial sweeteners and metabolic dysregulation.[vi],[vii]

Ironically, many “light” yogurt products include these artificial sweeteners as a key ingredient in the effort to retain palatability while reducing total sugars and calories. Consuming yogurt products in an effort to favorably modify the microbiome while consuming these “light” or “reduced calorie” additives may detrimentally undermine any beneficial changes to the microbiome the consumer anticipates.


[This is a short excerpt from the “Supporting the Microbial Ecosystem of the Gut” section of our newest Road map Functional Strategies for the Management of Gastrointestinal Disorders, which is now (finally) ready to be ordered.]


[i] Sylvetsky AC, Welsh JA, Brown RJ, Vos MB. Low-calorie sweetener consumption is increasing in the United States. Am J Clin Nutr. 2012 Sep;96(3):640-6.

[ii] Suez J, Korem T, Zilberman-Schapira G, et al. Non-caloric artificial sweeteners and the microbiome: findings and challenges. Gut Microbes. 2015;6(2):149-55.

[iii] Spencer M, Gupta A, Dam LV, et al. Artificial Sweeteners: A Systematic Review and Primer for Gastroenterologists. J Neurogastroenterol Motil. 2016 Apr 30;22(2):168-80.

[iv] Suez J, Korem T, Zeevi D, et al. Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature. 2014 Oct 9;514(7521):181-6.

[v] Nettleton JE, Reimer RA, Shearer J. Reshaping the gut microbiota: Impact of low calorie sweeteners and the link to insulin resistance? Physiol Behav. 2016 Apr 15. pii: S0031-9384(16)30164-0.

[vi] Palmnäs MS, Cowan TE, Bomhof MR, et al. Low-dose aspartame consumption differentially affects gut microbiota-host metabolic interactions in the diet-induced obese rat. PLoS One. 2014 Oct 14;9(10):e109841.

[vii] Abou-Donia MB1, El-Masry EM, Abdel-Rahman AA, et al. Splenda alters gut microflora and increases intestinal p-glycoprotein and cytochrome p-450 in male rats. J Toxicol Environ Health A. 2008;71(21):1415-29.