Coenzyme Q-10 has been used as a dietary supplement for a variety of uses over the past few decades. Among its many therapeutic benefits, are those related to heart failure symptoms and mortality. This past week the results of a large clinical trial were presented at a congress of the European Society of Cardiology Heart Failure Association. That study (Q-SYMBIO) showed that 300mg of daily CoQ-10 supplementation for 2 years had a highly significant effect on major adverse cardiovascular events (50% reduction) and all-cause mortality (>45% reduction). Here is a news reports about this study.
Since the full paper has not been published, it is difficult to assess the nuances of the data- something that has invited many to discount the potential benefits of these study results. The cautious, but optimistic conclusion of the study authors is that “CoQ10 should be considered as a part of the maintenance therapy of patients with chronic heart failure.”
*- Remember- Statin therapy reduced serum CoQ-10
Here are some more recent studies using CoQ-10 you might be interested in-
- Effect of coenzyme Q₁₀ supplementation on heart failure: a meta-analysis. Am J Clin Nutr. 2013 Feb;97(2):268-75.
- The effect of coenzyme Q10 in statin myopathy. Neuro Endocrinol Lett. 2012;33 Suppl 2:98-101.
- Impact of coenzyme Q-10 on parameters of cardiorespiratory fitness and muscle performance in older athletes taking statins. Phys Sportsmed. 2012 Nov;40(4):88-95.
- Can Coenzyme Q10 Improve Clinical and Molecular Parameters in Fibromyalgia? Antioxid Redox Signal. 2013 Apr 6.
- Coenzyme Q10 deficiency in mitochondrial DNA depletion syndromes. Mitochondrion. 2013 Jul;13(4):337-41.
- Coenzyme Q10 Supplementation Reduces Oxidative Stress and Increases Antioxidant Enzyme Activity in Patients with Relapsing-Remitting Multiple Sclerosis. Int J Neurosci. 2013 May 10.
- Coenzyme q10 regulates osteoclast and osteoblast differentiation. J Food Sci. 2013 May;78(5):H785-891.